After a 2-1 win over the Sounders on Wednesday night, Head Coach Jesse Marsch said Ryan Meara would start in goal for all remaining Open Cup matches, but after Meara took a knock in training on Thursday, he will not be available for tonight's match.
With Meara unavailable, Captain Luis Robles will start in goal.
The backline will be manned by Aurélien Collin, Connor Lade and Hassan Ndam, who all return to the Starting XI, and will be alongside Tim Parker and Kemar Lawrence.
Carlos Rivas, gets his first start since March 31 against Orlando City, and will serve as the teams' striker. Derrick Etienne, Jr., also returns to the starting lineup, as will Marc Rzatkowski.
Kaku, makes his return to the Red Bulls, after completing his international duty with the Paraguay National Team.
Tyler Adams will also be on the pitch for the starting whistle, too.
Fidel Escobar and Michael Amir Murillo are away with the Panama National team, competing in the 2018 FIFA World Cup.
With Meara missing the match, Evan Louro will serve as the backup goalkeeper, with Sean Davis, Aaron Long, Alex Muyl, Danny Royer, Florian Valot, and Bradley Wright-Phillips also available as subs.
The Red Bulls and Philadelphia Union kick off at 7 p.m. on NewYorkRedBulls.com, as well as on New York Red Bulls Radio.